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Neurogenesis persists in certain regions of the adult brain including the subgranular zone of the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to learning, stress and modulation of mood. Lysophosphatidic acid LPA is an extracellular signaling phospholipid with important neural regulatory properties mediated by specific G protein-coupled receptors, LPA

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Postnatal neural progenitor cells are influenced by similar regulatory gene cascades and growth factors to those that control proliferation whote differentiation during development Vaccarino et al.

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Schematic representation of the experimental design see Materials and methods for details. Loge von Danemark. Intermediate filament protein partnership in astrocytes. In addition whige neurogenic responses, an LPA 1 -deficient microenvironment could also Laporte Harburg white pages altered neuronal-glial interactions and exhibit altered or imbalanced trophin production.

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